among patients with COVID-19 that require treatment in intensive care for acute respiratory distress syndrome (ARDS), mortality has been reported between the 16 – 78% (1). In patients discharged alive, an increased risk of sequelae of anticipated COVID-19 (2). Hyperinflammatory response caused by SARS-CoV-2 is important in the pathogenesis COVID-19 and accompanied by a deregulated expression of interleukin 6 ( IL -6) were correlated with the severity of the disease (3 ).

Tocilizumab, monoclonal antibodies against IL -6 receptors originally licensed for use in rheumatoid arthritis, is also approved for the treatment of a chimeric antigen receptor T cell cytokine release syndrome-related and secondary hemophagocytic syndrome that shares important features with hyperinflammatory phase in COVID-19.

Several small studies from China and Europe have reported promising results of treatment with tocilizumab in patients with COVID-19, preventing the need for admission to intensive care units and improve clinical outcomes (4,5).

We aimed to evaluate the impact of treatment with tocilizumab compared with routine maintenance on important clinical outcomes in critically ill patients admitted to the intensive care unit with ARDS because COVID-19.

Tocilizumab shortens time on mechanical ventilation and length of hospital stay in patients with severe COVID-19: a retrospective cohort study
Tocilizumab shortens time on mechanical ventilation and length of hospital stay in patients with severe COVID-19: a retrospective cohort study

Hand, foot, and mouth of the baby because of coxsackievirus A6 in Shanghai

Background: Evidence of hand, foot and mouth disease (HFMD) in neonates is limited. The purpose of this study was to evaluate clinical symptoms, pathogens, possible transmission route, and prognosis of neonatal HFMD in Shanghai.


Methods: This study is a case-control study based surveillance system registry HFMD. All neonates and infected family members were enrolled between 2016 and 2017 in Shanghai. Neonates with HFMD were followed for at least half a year. Detailed questionnaires, medical history, and physical examination were recorded. routine examination of blood, liver and kidney function, immunophenotypes peripheral blood lymphocytes (CD3, CD4, and CD8 T-cells, NK cells), immunoglobulin (Ig) M, IgG, and IgA, and cytokine interleukin (IL-1β, IL-2R , IL-6, IL-8, IL-10, and TNF-α) levels were measured.

All rectal swab specimens were collected and genotypes of enteroviruses, and phylogenetic analysis based on sequence VP1 of coxsackievirus A6 (CV-A6) was conducted to investigate the molecular characteristics and evolution. T-test or nonparametric test was used to evaluate the difference. logistic analysis was applied to calculate the risk of clinical manifestations in the neonatal group and their brother paired HFMD.


Results: There were 16 neonates among 12 608 patients diagnosed with HFMD, accounting for 0.13%. All neonatal infection transmitted by other family members, especially the older brother, and is caused by the CV-A6. CV-A6 is the causative agent appears and dominant of HFMD in Shanghai. None of neonates with HFMD has a fever, onychomadesis, or severe complications. However, two patients older brothers showed lethargy, and an advanced hypoperfusion.

In older brother with HFMD, the proportion of white blood cells is generally higher than in neonates with HFMD. Immunological function of neonates with HFMD basically normal. Higher levels of inflammatory markers in both neonates and older brother with HFMD compared with controls of the same age. Clinical symptoms subsided about 1 week after the onset. None of the neonates had sequelae.

Bovine Interleukin 16 (IL16) ELISA Kit

EKN46340-96T 96T
EUR 584.6

Bovine Interleukin 16 (IL16) ELISA Kit

EKU05229-48T 48T
EUR 600.25

Bovine Interleukin 16 (IL16) ELISA Kit

EKU05229-5x96T 5x96T
EUR 4073.13

Bovine Interleukin 16 (IL16) ELISA Kit

EKU05229-96T 96T
EUR 857.5

Bovine Interleukin 16 (IL16) ELISA Kit

DL-IL16-b 96T
EUR 416
Description: serum, plasma or other biological fluids.

Bovine Interleukin 16 (IL16) ELISA Kit

EK14773 96Т
EUR 768

Bovine Interleukin 16 (IL16) ELISA Kit

RK06138 96T
EUR 280

Bovine Interleukin 16 (IL16) ELISA Kit

RDR-IL16-b-48T 48T
EUR 448.35
Description: serum, plasma and other biological fluids.

Bovine Interleukin 16 (IL16) ELISA Kit

RDR-IL16-b-48Tests 48 Tests
EUR 619.2

Bovine Interleukin 16 (IL16) ELISA Kit

RDR-IL16-b-96T 96T
EUR 640.5
Description: serum, plasma and other biological fluids.

Bovine Interleukin 16 (IL16) ELISA Kit

RDR-IL16-b-96Tests 96 Tests
EUR 859.2

Bovine Interleukin 16 (IL16) ELISA Kit

RD-IL16-b-48T 48T
EUR 427
Description: serum, plasma and other biological fluids.

Bovine Interleukin 16 (IL16) ELISA Kit

RD-IL16-b-48Tests 48 Tests
EUR 592.8

Bovine Interleukin 16 (IL16) ELISA Kit

RD-IL16-b-96T 96T
EUR 610
Description: serum, plasma and other biological fluids.

Bovine Interleukin 16 (IL16) ELISA Kit

RD-IL16-b-96Tests 96 Tests
EUR 820.8

Bovine Interleukin 1β (IL- 1β) Elisa kit

EK760123 96 Wells
EUR 0.91

Bovine Interleukin 1β (IL- 1β) ELISA kit

EKC40911-48T 48T
EUR 474.04

Bovine Interleukin 1β (IL- 1β) ELISA kit

EKC40911-5x96T 5x96T
EUR 3216.7

Bovine Interleukin 1β (IL- 1β) ELISA kit

EKC40911-96T 96T
EUR 677.2

Bovine Interleukin 1β (IL- 1β) ELISA kit

CSB-E12986B-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Bovine Interleukin 1β (IL- 1β) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Bovine Interleukin 1β (IL- 1β) ELISA kit

1-CSB-E12986B
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  • 1 plate of 96 wells
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  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Bovine Interleukin 1β (IL- 1β) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Rat IL-16(Interleukin 16) ELISA Kit

EKF60518-48T 48T
EUR 396.9

Rat IL-16(Interleukin 16) ELISA Kit

EKF60518-5x96T 5x96T
EUR 2693.25

Rat IL-16(Interleukin 16) ELISA Kit

EKF60518-96T 96T
EUR 567

Rat IL-16(Interleukin 16) ELISA Kit

E39ER1089 96T
EUR 595

Rat IL-16(Interleukin 16) ELISA Kit

ER1089 96T
EUR 571.5
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 9.375pg/ml

Rat IL-16(Interleukin 16) ELISA Kit

RE1119R-48wells 48 wells
EUR 125.55

Rat IL-16(Interleukin 16) ELISA Kit

RE1119R-96wells 96 wells
EUR 179.55

Rabbit IL-16(Rabbit IL-16(Interleukin 16)) ELISA Kit

ERB0139 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rabbit;Sensitivity: 9.375pg/ml

Human IL-16(Interleukin 16) ELISA Kit

EH0178 96T
EUR 571.5
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75pg/ml

Mouse IL-16(Interleukin 16) ELISA Kit

EKF58085-48T 48T
EUR 396.9

Mouse IL-16(Interleukin 16) ELISA Kit

EKF58085-5x96T 5x96T
EUR 2693.25

Mouse IL-16(Interleukin 16) ELISA Kit

EKF58085-96T 96T
EUR 567

Human IL-16 (Interleukin 16) ELISA Kit

EKE60179-5x96T 5x96T
EUR 2667.6

Human IL-16 (Interleukin 16) ELISA Kit

EKE60179-96T 96T
EUR 561.6

Human IL-16(Interleukin 16) ELISA Kit

E39EH0178 96T
EUR 595

Mouse IL-16(Interleukin 16) ELISA Kit

E39EM1157 96T
EUR 595

Mouse IL-16(Interleukin 16) ELISA Kit

EM1157 96T
EUR 571.5
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 9.375pg/ml

Human IL-16(Interleukin 16) ELISA Kit

RE1119H-48wells 48 wells
EUR 125.55

Human IL-16(Interleukin 16) ELISA Kit

RE1119H-96wells 96 wells
EUR 179.55

Bovine Interleukin-8(IL-8) Elisa kit

EK760180 96 Wells
EUR 0.91

Bovine Interleukin-6 (IL-6) ELISA Kit

IBOIL6KT each
EUR 825
Description: Bovine Interleukin-6 (IL-6) ELISA Kit

Monkey IL-16(Interleukin 16) ELISA Kit

EMK0038 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Ape;Sensitivity: 18.75pg/ml

Bovine interleukin 16 (lymphocyte chemoattractant factor) (IL16) Elisa kit

EK760122 96 Wells
EUR 0.91

Bovine Interleukin-10,IL-10 ELISA Kit

SL0209Bo - Ask for price

Porcine IL-16(Interleukin 16) ELISA Kit

EP0089 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Pig;Sensitivity: 9.375pg/ml

IL-8 ELISA Kit| Bovine Interleukin 8 ELISA Kit

EF010973 96 Tests
EUR 826.8

IL-6 ELISA Kit| Bovine Interleukin 6 ELISA Kit

EF010982 96 Tests
EUR 826.8

IL-2 ELISA Kit| Bovine Interleukin 2 ELISA Kit

EF011039 96 Tests
EUR 826.8

Bovine Interleukin-17A, IL-17 ELISA Kit

ELA-E1700b 96 Tests
EUR 1113.6

IL-10 ELISA Kit| Bovine Interleukin 10 ELISA Kit

EF011027 96 Tests
EUR 826.8

Human Interleukin-16 (IL-16) ELISA Kit

IHUIL16KT each
EUR 702
Description: Human Interleukin-16 (IL-16) ELISA Kit

Human Interleukin-16 (IL-16) ELISA Kit

LF-EK60020 1×96T
EUR 948

Bovine Interleukin 1(IL-1) Elisa Kit

EK760114 96 Wells
EUR 0.9

Bovine Interleukin 2,IL-2 Elisa Kit

EK760125 96 Wells
EUR 0.91

Bovine interleukin 4 (IL-4) Elisa Kit

EK760131 96 Wells
EUR 0.91

Bovine Interleukin 5 (IL-5) Elisa Kit

EK760133 96 Wells
EUR 0.91

Bovine Interleukin 6(IL-6 ) Elisa Kit

EK760134 96 Wells
EUR 0.91

Bovine Interleukin 8,IL-8 Elisa Kit

EK760135 96 Wells
EUR 0.91

Bovine Interleukin 2,IL-2 ELISA Kit

EKC40692-48T 48T
EUR 439.25

Bovine Interleukin 2,IL-2 ELISA Kit

EKC40692-5x96T 5x96T
EUR 2980.63

Bovine Interleukin 2,IL-2 ELISA Kit

EKC40692-96T 96T
EUR 627.5

Bovine Interleukin 1,IL-1 ELISA Kit

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EUR 400.68

Bovine Interleukin 1,IL-1 ELISA Kit

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EUR 2718.9

Bovine Interleukin 1,IL-1 ELISA Kit

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EUR 572.4

Bovine interleukin 4,IL-4 ELISA Kit

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EUR 631.26

Bovine interleukin 4,IL-4 ELISA Kit

EKC40897-5x96T 5x96T
EUR 4283.55

Bovine interleukin 4,IL-4 ELISA Kit

EKC40897-96T 96T
EUR 901.8

Bovine Interleukin 6,IL-6 ELISA Kit

EKC40898-48T 48T
EUR 631.26

Bovine Interleukin 6,IL-6 ELISA Kit

EKC40898-5x96T 5x96T
EUR 4283.55

Bovine Interleukin 6,IL-6 ELISA Kit

EKC40898-96T 96T
EUR 901.8

Bovine Interleukin 8,IL-8 ELISA Kit

EKC40925-48T 48T
EUR 597.24

Bovine Interleukin 8,IL-8 ELISA Kit

EKC40925-5x96T 5x96T
EUR 4052.7

Bovine Interleukin 8,IL-8 ELISA Kit

EKC40925-96T 96T
EUR 853.2

Bovine Interleukin 1 (IL-1) ELISA Kit

EK11240 96Т
EUR 799

Bovine Interleukin 6 (IL-6) ELISA Kit

EK10271 96Т
EUR 799

Bovine Interleukin 1 (IL-1) ELISA Kit

AE58511BO-48Tests 48 Tests
EUR 260
Description: Bovine (Bos taurus; Cattle)

Bovine Interleukin 1 (IL-1) ELISA Kit

AE58511BO-96Tests 96 Tests
EUR 480
Description: Bovine (Bos taurus; Cattle)

Bovine Interleukin 8 (IL-8) ELISA Kit

AE38182BO-48Tests 48 Tests
EUR 360
Description: Bovine (Bos taurus; Cattle)

Bovine Interleukin 8 (IL-8) ELISA Kit

AE38182BO-96Tests 96 Tests
EUR 680
Description: Bovine (Bos taurus; Cattle)

Bovine Interleukin 6 (IL-6) ELISA Kit

AE38214BO-48Tests 48 Tests
EUR 360
Description: Bovine (Bos taurus; Cattle)

Bovine Interleukin 6 (IL-6) ELISA Kit

AE38214BO-96Tests 96 Tests
EUR 680
Description: Bovine (Bos taurus; Cattle)

Bovine Interleukin 2, IL-2 ELISA Kit

CSB-E09810b-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Bovine Interleukin 2, IL-2 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Bovine Interleukin 2, IL-2 ELISA Kit

1-CSB-E09810b
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Description: Quantitativesandwich ELISA kit for measuring Bovine Interleukin 2, IL-2 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Bovine Interleukin 1, IL-1 ELISA Kit

CSB-E12019B-24T 1 plate of 24 wells
EUR 198
Description: Quantitativecompetitive ELISA kit for measuring Bovine Interleukin 1, IL-1 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Bovine Interleukin 1, IL-1 ELISA Kit

1-CSB-E12019B
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Description: Quantitativecompetitive ELISA kit for measuring Bovine Interleukin 1, IL-1 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Bovine Interleukin 5 (IL-5) ELISA Kit

CSB-E12897B-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Bovine Interleukin 5 (IL-5) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Bovine Interleukin 5 (IL-5) ELISA Kit

1-CSB-E12897B
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  • 1 plate of 96 wells
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Description: Quantitativesandwich ELISA kit for measuring Bovine Interleukin 5 (IL-5) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Bovine interleukin 4, IL-4 ELISA Kit

CSB-E12898B-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Bovine interleukin 4, IL-4 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Bovine interleukin 4, IL-4 ELISA Kit

1-CSB-E12898B
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  • 1 plate of 96 wells
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  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Bovine interleukin 4, IL-4 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Bovine Interleukin 6, IL-6 ELISA Kit

CSB-E12899B-24T 1 plate of 24 wells
EUR 198
Description: Quantitativecompetitive ELISA kit for measuring Bovine Interleukin 6, IL-6 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Bovine Interleukin 6, IL-6 ELISA Kit

1-CSB-E12899B
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  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativecompetitive ELISA kit for measuring Bovine Interleukin 6, IL-6 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Bovine Interleukin 8, IL-8 ELISA Kit

CSB-E13052B-24T 1 plate of 24 wells
EUR 198
Description: Quantitativecompetitive ELISA kit for measuring Bovine Interleukin 8, IL-8 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Bovine Interleukin 8, IL-8 ELISA Kit

1-CSB-E13052B
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  • 1 plate of 96 wells
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Description: Quantitativecompetitive ELISA kit for measuring Bovine Interleukin 8, IL-8 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Bovine Interleukin 2(IL-2) ELISA Kit

GA-E0014BV-48T 48T
EUR 403.2

Bovine Interleukin 2(IL-2) ELISA Kit

GA-E0014BV-96T 96T
EUR 640.8

Bovine Interleukin 6(IL-6) ELISA Kit

GA-E0018BV-48T 48T
EUR 403.2

Bovine Interleukin 6(IL-6) ELISA Kit

GA-E0018BV-96T 96T
EUR 640.8

Bovine Interleukin 6(IL-6)ELISA Kit    

NSL1678Bo 96 T
EUR 528

Bovine Interleukin 8(IL-8)ELISA Kit  

NSL1679Bo 96 T
EUR 528

Bovine Interleukin 1(IL-1) ELISA Kit

NSL0432Bo 96 T
EUR 528

Bovine Interleukin 2(IL-2) ELISA Kit

NSL0440Bo 96 T
EUR 528

Bovine Interleukin 3(IL-3) ELISA Kit

NSL0445Bo 96 T
EUR 528

Bovine Interleukin 4(IL-4) ELISA Kit

NSL0446Bo 96 T
EUR 528

Bovine Interleukin 5(IL-5) ELISA Kit

NSL0447Bo 96 T
EUR 528

Bovine Interleukin 7(IL-7) ELISA Kit

NSL0449Bo 96 T
EUR 528

Bovine Interleukin 9(IL-9) ELISA Kit

NSL0450Bo 96 T
EUR 528

Bovine Interleukin 2,IL-2 ELISA Kit

QY-E60003 96T
EUR 511.2

Bovine Interleukin 6,IL-6 ELISA Kit

QY-E60008 96T
EUR 511.2

Bovine Interleukin 8,IL-8 ELISA Kit

QY-E60024 96T
EUR 511.2

Bovine Interleukin 4,IL-4 ELISA Kit

QY-E60027 96T
EUR 511.2

Bovine Interleukin 2 (IL-2) ELISA Kit

RK09288 96T
EUR 280

Bovine Interleukin 6 (IL-6) ELISA Kit

RK09289 96T
EUR 280

Bovine Interleukin 8 (IL-8) ELISA Kit

RK09290 96T
EUR 280

Bovine Interleukin 3 (IL-3) ELISA Kit

RK06163 96T
EUR 280

Bovine Interleukin 4 (IL-4) ELISA Kit

RK06166 96T
EUR 280

Bovine Interleukin 5 (IL-5) ELISA Kit

RK06167 96T
EUR 280

Bovine Interleukin 2,IL-2 ELISA Kit

SL0006Bo -
EUR 528

Bovine Interleukin 6,IL-6 ELISA Kit

SL0007Bo -
EUR 528

Bovine Interleukin 8(IL-8) ELISA Kit

SL0077Bo -
EUR 528

Bovine Interleukin 4, IL-4 ELISA Kit

SL0208Bo - Ask for price

Bovine Interleukin 5,IL-5 ELISA KIT

YLA0384BO-48T 48T Ask for price

Bovine Interleukin 5,IL-5 ELISA KIT

YLA0384BO-96T 96T Ask for price

Bovine Interleukin 4,IL-4 ELISA Kit

YLA0026BO-48T 48T Ask for price

Bovine Interleukin 4,IL-4 ELISA Kit

YLA0026BO-96T 96T Ask for price

Bovine Interleukin 2,IL-2 ELISA kit

YLA0031BO-48T 48T Ask for price

Bovine Interleukin 2,IL-2 ELISA kit

YLA0031BO-96T 96T Ask for price

Bovine Interleukin 1,IL-1 ELISA Kit

YLA0051BO-48T 48T Ask for price

Bovine Interleukin 1,IL-1 ELISA Kit

YLA0051BO-96T 96T Ask for price

Bovine Interleukin 8,IL-8 ELISA Kit

YLA0066BO-48T 48T Ask for price

Bovine Interleukin 8,IL-8 ELISA Kit

YLA0066BO-96T 96T Ask for price

Bovine Interleukin 6,IL-6 ELISA Kit

YLA0067BO-48T 48T Ask for price

Bovine Interleukin 6,IL-6 ELISA Kit

YLA0067BO-96T 96T Ask for price

Bovine IL-8(Interleukin 8) ELISA Kit

EKF60731-48T 48T
EUR 396.9

Bovine IL-8(Interleukin 8) ELISA Kit

EKF60731-5x96T 5x96T
EUR 2693.25

Bovine IL-8(Interleukin 8) ELISA Kit

EKF60731-96T 96T
EUR 567

Bovine IL-6(Interleukin 6) ELISA Kit

EKF60732-48T 48T
EUR 396.9

Bovine IL-6(Interleukin 6) ELISA Kit

EKF60732-5x96T 5x96T
EUR 2693.25

Bovine IL-6(Interleukin 6) ELISA Kit

EKF60732-96T 96T
EUR 567

Bovine IL-4(Interleukin 4) ELISA Kit

EB0150 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Cattle ;Sensitivity: 9.375pg/ml

Bovine IL-8(Interleukin 8) ELISA Kit

EB0007 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Cattle;Sensitivity: 18.75pg/ml

Bovine IL-6(Interleukin 6) ELISA Kit

EB0028 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Cattle;Sensitivity: 9.375pg/ml

Bovine IL-2(Interleukin 2) ELISA Kit

EB0087 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Cattle;Sensitivity: 18.75pg/ml

Bovine Interleukin 10,IL-10 Elisa Kit

EK760113 96 Wells
EUR 0.9

Bovine Interleukin 12,IL-12 Elisa Kit

EK760117 96 Wells
EUR 0.9


Conclusions: In our study, the CV-A6 infection in neonates are benign, but it has the character of a family grouping. Because the two-child policy in China, the elder brother may be the main route of transmission of HFMD.